Melanotan 2 is a synthetic variant of naturally occurring peptide hormone in the body which helps in stimulation of melanogenesis. Melanogenesis is the process by which melanin pigments are produced on the skin. The Alpha Melanocyte stimulating hormone or MSH activates melanocortin receptor. MSH also has influence over appetite, sexual libido, and lipid metabolism through the melanocortin receptors. Hence, Melanotan 2 shows lipolytic, libido enhancing and appetite suppressant properties. It also has the properties of inducing skin tanning, which is said to be useful in protecting skin against ill effects of UVradiations.
Another variant of Melanotan 2, known as PT- 141 is being studied as a remedy for sexual disorders, mainly male erectile dysfunction. Purchasing peptides for research purposes has been made easy with several online sites that sell quality research peptides.
Development of Melanotan 2
The university of Arizona could be credited for the creation of Melanotan 2. Melanotan 2 was primarily synthesized to use as a protection from skin cancer. This works by stimulating melanogenesis, causing the production of the pigment melanin, which protects the skin from direct exposure from UV. Initially, researchers tried to directly harness and administer MSH but it proved very difficult for long-term use, hence a synthetic replacement was made. Melanotan 2 exhibits long half- life, which proves suitable for therapeutic purposes.
Studies on Melanotan 2
Melanotan 2 and Melanotan are analogs of hormone alpha- Melanocyte Stimulating Hormone that induces tanning. Melanotan 2 exhibits aphrodisiac properties, which is not seen in Melanotan 1. This has an additional effect on increasing libido.
Effects of the hormone on mice have been studied in laboratory mice. Central melanocortin was observed to be activated when Melanotan 2 has been fed to the mice. It was also observed that after 6 days of Melanotan treatment there was a loss in adipose tissue and body weight. This has implied that Melanotan may prove useful in the treatment of obesity. Studies have also shown that oxygen consumption has increased in treated mice. Levels of insulin and cholesterol were also seen to be much lower when compared to other treatments.
Alpha-Melanocyte-Stimulating Hormone Analogues
The alpha- melanocyte stimulating hormone is a natural hormone that is important in stimulating melanogenesis, which regulates for skin and hair pigmentation. Alpha-MSH also regulates feeding behavior, sexual activity, and homeostasis. MSH is an agonist of melanocortin receptors MC1, MC3, MC4 and MC 5. Melanotan 1 and 2 stimulate MC1 receptor. This is responsible for skin pigmentation. PT-141 and Melnotan2 stimulate MC3 and MC4 which regulate appetite, sexual behavior, and metabolism. However, MC1 is not stimulated by PT- 141.
Other synthetic analogs of Melanocyte Stimulating Hormone have also been studied for their photoreceptive functions on skin against radiation from sun and UV. These analogs are Melanotan and Melanotan II, which is also known as Melanotan 2. Another analogue of the same hormone, Bremelanotide is under study and development to treat erectile dysfunction.
Only for Research
Even though there is a lot of research on Melanotan 2, the results obtained and the determined effects were only based on animal testing under laboratory condition. It is also important to note that the synthetic peptide is under study and only used for research purposes. All the benefits, functions, and mechanics are based on the results obtained from tests under contained environment.